课程概况
The University of California San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences Drug Discovery course brings you lectures from both faculty and industry experts. With this course, recorded on campus at UCSD, we seek to share our access to top people in the field who bring an unprecedented range of expertise on drug discovery.
In this course you will learn the drug discovery process up to the filing of an Initial New Drug Application or IND. Each week you will learn the steps that a pharmaceutical or biotech company goes through to discover a new therapeutic drug. In this course you will be able to:
* Understand the pharmaceutical and biotechnology market a changing landscape
* Learn the major aspects of the drug discovery process, starting with target selection, to compound screening to designing lead candidates.
* Recognize current modern drug discovery based on the lock-and-key theory, which attempts to use one single compound to hit one target to combat the related disease.
* Increase understanding of the various drug discovery tools and methods that are used for finding, identifying and designing a new drug.
* Define and understand the regulatory responsibilities for drug discovery to file an Investigational New Drug Application (IND).
This course is intended as part 1 of a series: Drug Discovery, Drug Development (https://www.coursera.org/learn/drug-development) and Drug Commercialization (https://www.coursera.org/learn/drug-commercialization). We would highly recommend that you take the courses in order since it will give you a better understanding on how a drug is discovered in the lab before being tested in clinical trials and then launched in the market place.
课程大纲
Welcome!
Pharmaceutical & Biotechnology Industry Landscape
In this module course lead Dr. Williams Ettouati begins by giving a landscape overview of the Pharma and Biotechnology landscape.
Drug Discovery: Proteomics, Genomics
This week we will be hearing from Phillip Bourne, PhD. Dr. Bourne was, at the time of this recording, the Associate Vice Chancellor for Innovation and Industrial Alliances in the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences. Since that time, he has been named the first Associate Director for Data Science at the United States National Institutes of Health.
Compound Selection & Preclinical Studies
This week we will hear from Ronald Christopher, Ph.D. Dr. Ronald Christopher, Vice President of Preclinical Trials at Arena Pharmaceuticals.
Challenges in Fragment Based Drug Discovery for Protein Kinases
In this module we will hear from Stephen Burley, M.D., Ph.D. At the time of this recording, Director of the Center for Integrative Proteomics at Rutgers University. He is now the Director of the Protein Data Bank and remains an Adjunct Professor at the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences.
Key Concepts in Drug Delivery
This module we hear from Professor of Clinical Pharmacy and Pediatrics, Brookie Best, Pharm. D., of UCSD's Skaggs School of Pharmacy and Pharmaceutical Sciences.
