Demonstrate an understanding of the biological relevance of metabolites (the small molecular weight intermediates and products of metabolism) and the metabolome
Assess the challenges involved in studying the metabolome
Develop an awareness of the analytical techniques and data analysis tools that are applied to study the metabolome
Evaluate how the interaction of scientists from different disciplines has driven the development of this field
Metabolomics is an emerging field that aims to measure the complement of metabolites (the metabolome) in living organisms. The metabolome represents the downstream effect of an organism’s genome and its interaction with the environment. Metabolomics has a wide application area across the medical and biological sciences. The course provides an introduction to metabolomics, describes the tools and techniques we use to study the metabolome and explains why we want to study it. By the end of the course you will understand how metabolomics can revolutionise our understanding of metabolism.
Metabolism and the interaction of the metabolome with the genome, proteome and the environment
The advantages of studying the metabolome
The application of hypothesis generating studies versus the use of traditional hypothesis directed research
The use of targeted and non-targeted studies in metabolomics
An interdisciplinary approach with case-studies from clinical and environmental scientific areas
Important considerations in studying the metabolome
Experimental design and sample preparation
The application of mass spectrometry in metabolomics
An introduction to data processing and analysis
The course is primarily aimed at final year undergraduate science students and research scientists who are interested in learning about the application of metabolomics to understand metabolism. However, metabolomics is a new tool to the scientific community and this course will provide a valuable introduction to scientists at any stage in their careers. It is not essential to have any previous knowledge of the subject area but a reasonable knowledge and understanding of science would be beneficial.