Two major types of immune reactions. Complement system, Pathogen recognition, Production mechanism of various antibodies, Cells and molecules working in them.
Mechanisms of innate immunity, Names and functions of major molecules involved in innate immunity.
Involvement of adaptive immune system cells in autoimmune diseases and cancers.
Reaction mechanisms of vaccines.
Intestinal barrier functions, roles of commensal bacteria, functions of unique immune cells in the intestinal mucosa.
This course will provide fundamental knowledge in immunology as well as some advanced topics from cutting-edge research results, such as cancer immunotherapy and novel vaccine development.
Immunity is the body’s system of protection from attack by pathogens such as bacteria and viruses. Immunology has a long history, and researchers around the world faced with the “enemies of human life” have solved numerous immunological mysteries, and contributed to a paradigm shift in immunology. Nonetheless, it is as yet unknown how certain diseases like AIDS, influenza and allergies can be completely conquered. The latest immunological research is revealing that immunity is also strongly correlated with an increasing number of other diseases such as cancer, arteriosclerosis and diabetes. If we could fully understand the mechanism of immunity, we should be able to treat such diseases. We would like to introduce basic knowledge of immunology revealed by past research and share our insights on the latest findings with you for the future development of immunology.
During this course you will learn the mechanisms of the immune system and deepen your understanding of forefront immunology research and development of medical applications. We especially encourage young people who are interested in life-science and immunology to join this course, as it will assist consideration of immunology research as a career.
The part one of the course consists of 5 lectures of about 90 minutes each. The first week covers introductory subjects and specific topics follow from the second week.
WEEK1: Overview of Immunology
What is the immune system?
Players act in the immune system
How various types of immune cells work in the immune system?
WEEK2: Innate Immunity
2-1: Innate Immunity- Pathogen Recognition by Innate Immunity
Mechanism of innate immunity
Interaction between innate immunity and adaptive immunity
Pattern recognition receptors
2-2: Innate Immunity - Disorder-specific M2 Macrophages
Functions of macrophages
Recent topics in the research for various types of M2 macrophages
2-3: Innate Immunity - Understanding and Manipulation of the NLRP3-inflammasome
Colchicine inhibits activation of the NLRP3-inflammasome
Autophagy limits activation of the NLRP3-inflammasome
WEEK 3: Adaptive Immunity 1 - Control of Immune Responses by Regulatory T Cells
Identification of regulatory T (Treg) cells
FoxP3 is a Treg specific transcription factor, and it controls IL-2 production
Treg-targeting cancer immunotherapy
WEEK 4: Adaptive Immunity 2
4-1: Adaptive Immunity 2 - Immune Regulatory Mechanisms through B Cell Axis
Anti-inflammatory functions by B cell
Regulatory function of plasmablasts to suppress Experimental Autoimmune Encephalomyelitis (EAE)
Essential signaling factors in B cells for IL-10 production
4-2: Adaptive Immunity 2 - Vaccine & Immunological Memory
What is vaccine (vaccination)?
What is immunological memory?
What are the issues in the research for immunological memory?
WEEK 5: Mucosal Immunology
Barrier functions of epithelial cells
Intestinal environmental factors
Unique immune cells in the intestinal mucosa