分子生物学-第1部分:DNA复制和修复

Molecular Biology - Part 1: DNA Replication and Repair

An in-depth adventure through DNA replication and repair to strengthen your scientific thinking and experimental design skills.

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麻省理工学院
edX
  • 完成时间大约为 8
  • 高级
  • 英语, 中文
注:因开课平台的各种因素变化,以上开课日期仅供参考

你将学到什么

How to compare and contrast the mechanisms of DNA replication in prokaryotes and eukaryotes

How to describe several enzymatic mechanisms that the cell uses to repair or tolerate DNA damage

How to analyze protein structures to infer functional information

How to designmethods for the best experiment to test a hypothesis related to DNA replication or repair proteins

How to interpret data from DNA replication and repair experiments

课程概况

You’re acquainted with your DNA, but did you know that your cells synthesize enough DNA during your lifetime to stretch a lightyear in length? How does the cellular machinery accomplish such a feat without making more mistakes than you can survive? Why isn’t the incidence of cancer even higher than it is? And, if the DNA in each and every cell is two meters long, how is this genetic material compacted to fit inside the cell nucleus without becoming a tangled mess?

Are you ready to go beyond the “what” of scientific information presented in textbooks and explore how scientists deduce the details of these molecular models?

Take a behind-the-scenes look at modern molecular genetics, from the classic experimental events that identified the proteins involved in DNA replication and repair to cutting-edge assays that apply the power of genome sequencing. Do you feel confident in your ability to design molecular biology experiments and interpret data from them? We’ve designed the problems in this course to build your experimental design and data analysis skills.

Let’s explore the limits of our current knowledge about the replication machinery and pathways that protect the fidelity of DNA synthesis. If you are up for the challenge, join us in 7.28x Part 1: DNA Replication and Repair.

Follow the latest news from MITx Biology @MITxBio on Twitter .

预备知识

7.00x Introduction to Biology or similar (biochemistry, molecular biology, and genetics).

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